• br Genetic basis Similar to other

  2019-06-15

  

  Genetic basis Similar to other arrhythmia syndromes, Brugada and early repolarization syndromes are inherited diseases that are usually transmitted in an autosomal-dominant manner [26]. To date, 13 genes have been associated with Brugada syndrome. Loss-of-function mutations in SCN5A, encoding the

• br The L type calcium channel LTCC in

  2019-06-15

  

  The L-type calcium channel (LTCC) in heart consists of 4 subunits: α1, β2, α2, and δ [47], encoded by CACNA1C, CACNB2, and CACNA2D, respectively, with the α2 and δ subunits encoded by the gene CANA2D. In 2007, Antzelevitch et al. [48] reported 2 CACNA1C mutations and a CACNB2 mutation from a genot

• br Conflict of interest br Acknowledgment br

  2019-06-15

  

  Conflict of interest Acknowledgment Introduction Several investigators recently showed that the superior vena cava (SVC) was one of the major foci for initiating atrial tachyarrhythmias, such as atrial tachycardia (AT) and atrial fibrillation (AF) [1–4]. Conduction block between the atrium

• Confluye aqu en su literalidad

  2019-06-15

  

  Confluye aquí, en su literalidad, en su capacidad para evocar cierta “representación pura y simple de lo real”, esa retórica del cuerpo irak inhibitor la que hice referencia más arriba. “Cuerpo-texto que destruye el cuerpo-carne pero se monta en él para transformarlo, para sustituirlo”, en la Histor

• Para Rozitchner la di spora

  2019-06-14

  

  Para Rozitchner, la diáspora proporcionaba la posibilidad de averiguar por qué los sujetos políticos de los años setenta —entre los que se incluía— produjeron una fantasía y una idealidad sobre la materialidad de las fuerzas históricas. Y también, de advertir por qué el terror fue negado y excluido

• br Since the publication of

  2019-06-14

  

  Since the publication of Stillbirths Series in 2011, attention to the more than 2·6 million stillbirths that occur every year has become more visible in global and national maternal and neonatal health strategies. However, we continue to neglect the millions of women who experience not only still

• The miR signature of exosomes isolated from bulk prostate

  2019-06-14

  

  The miR signature of exosomes isolated from bulk prostate cancer aa-dutp (Fig. 1A, blue cells) and from their cancer stem cell compartment (Fig. 1A, green cells), display high levels of miR-21, miR-30 and miR-218 [23] (Fig. 1A, blue arrow). miR-21 and miR-30 have been identified as key regulators of

• br Discussion It is generally known that

  2019-06-14

  

  Discussion It is generally known that primary CNS melanomas are rare and difficult to diagnose prior to biopsy. According to tumor melanin content, four subtypes of malignant intracranial melanoma have been proposed, associated with different MRI image presentations. These subtypes are: 1) melano

• Sus l neas escupen desprecio por los conquistadores

  2019-06-14

  

  Sus líneas escupen desprecio por los conquistadores que se pliegan ion channels los designios de los letrados del rey en vez de liquidarlos, y son “hombres chicos y grandes pues consienten entrar un bachiller donde ellos trabajaron y no matarlos a todos pues son causa de tantos males”. De los indult

• br Radiotherapy for bone metastases As a palliative interven

  2019-06-13

  

  Radiotherapy for bone metastases As a palliative intervention, radiotherapy is effective and efficient at treating painful bone metastases, and the side effects associated with its use are manageable and usually self-limiting in nature. Between 50% and 80% of patients gain at least partial relief

• In this study all tumors were Campanacci stage

  2019-06-13

  

  In this study, all tumors were Campanacci stage 3, which is a significantly higher proportion than in our database [9]. Such a high stage usually suggests that a tumor is highly aggressive and may be a high-risk factor for lung metastasis. Previous reports have also suggested that the stage of a GCT

• We discussed in our report the potential to

  2019-06-13

  

  We discussed in our report the potential to improve vaccine acceptance and increase demand for OPV by engaging people within communities to deliver health education. Our analysis focused on all reported sources of health education within a community—ie, not only traditional leaders but also the loca

• bcl-2 inhibitor Pero el fuerte del comercio exterior argenti

  2019-06-13

  

  Pero el fuerte del comercio exterior argentino no sólo estuvo centrado en la demanda china, también Latinoamérica fue un mercado importante para las exportaciones. En este sentido, Daniel Berrettoni y Mariángeles Polonsky sostienen que fue clave “la importancia y el dinamismo del mercado brasileño c

• In this study we analyzed the

  2019-06-13

  

  In this study, we analyzed the biological effects of two novel GATA2 mutations, which were identified in adult de novo AML patients. Materials and methods The diagnosis of AML was based on the morphology, histopathology, the expression of leukocyte differentiation hmg-coa reductase and/or the F

• br Authorship br Conflict of interest disclosure

  2019-06-13

  

  Authorship Conflict of interest disclosure Introduction The Aurora kinases are serine/threonine protein kinases essential for regulation of normal hdac inhibitor mitosis. Aurora kinases A (AAK) and B are overexpressed in hematologic malignancies, including acute myeloid leukemia (AML) and

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