• In normal embryogenesis the left cardinal vein involutes to

  2019-05-05

  

  In normal embryogenesis, the left cardinal vein involutes to form the ligament of Marshall, the right cardinal vein and the superior connection between the left and right cardinal veins persist to form the superior vena cava and the brachiocephalic vein, respectively. PLSVC is when involution of the

• br Conclusions br Conflict of interest br

  2019-05-05

  

  Conclusions Conflict of interest Introduction Arrhythmogenic right ventricular cardiomyopathy (ARVC), previously called arrhythmogenic right ventricular dysplasia (ARVD), is an inherited disease characterized by right ventricular degeneration and ventricular arrhythmias. ARVC is one of the

• br El Movimiento Espa ol ha sido definido por

  2019-05-05

  

  El Movimiento Español 1959, ha sido definido por Eduardo Mateo Gambarte como: “el último latido de los más jóvenes exiliados por incorporarse Bindarit la lucha antifranquista”. Pese a su limitado número de participantes y su corto recorrido, representó un fenómeno destacable al estar encabezado po

• Entre las publicaciones de indagaci n epistemol gica

  2019-05-05

  

  Entre las publicaciones de indagación epistemológica se incluyen aquellas que plantean los cuestionamientos al pensamiento científico de la época y otras que reflexionan sobre la investigación científica, sus desarrollos y consecuencias iatrogénicas. Sobre estos particulares, se destaca la necesidad

• X rays commonly show a typical licked

  2019-05-04

  

  X-rays commonly show a typical licked candy stick appearance, based on concentric bone resorption. Common blood tests are usually normal, but bone alkaline phosphatase (BAP) may be elevated if a fracture occurred [8]. GSD is a diagnosis of exclusion. Diseases responsible of bone osteolysis such as i

• Mismo fen meno se observa

  2019-05-04

  

  Mismo fenómeno se observa en El Museo Mexicano, publicación ciertamente exitosa y donde se dieron cita los escritores más sobresalientes de la literatura mexicana decimonónica entre los años 1843 hasta 1846. El epígrafe que remata la portada constituye, en términos programáticos, todo una declaració

• br Introduction Liver fibrosis cirrhosis is a global health

  2019-05-04

  

  Introduction Liver fibrosis/cirrhosis is a global health problem that leads to morbidity and mortality. Alcohol abuse is one of the most common causes of liver fibrosis/cirrhosis in western developed countries and accounts for more than 50% of cirrhosis cases. Alcoholic liver fibrosis is characte

• Su acci n en Chiapas fracas no s lo por

  2019-05-04

  

  Su acción en Chiapas fracasó, no sólo por el rechazo que generó entre los encomenderos sino también entre los religiosos que apoyaban la encomienda en beneficio propio o bien como mecanismo de cristianización acelerado. Cuando Las Casas regresa eg5 España, en lo que hace a su batalla de ideas, a la

• Regarding the expression of NKp NCR Fig

  2019-05-04

  

  Regarding the expression of NKp46/NCR1 (Fig. 1A and B), both increased and decreased expression are observed depending on patients. Interestingly, the expression of the inducible molecule NKp44/NCR2 is clearly induced in 3 patients (PT1, PT2 and PT5) both regarding the percentage and the MFI. In con

• In an earlier study we used a questionnaire

  2019-05-04

  

  In an earlier study, we used a questionnaire to assess musculoskeletal pain in patients with CML who had achieved DMR (MR4.0) and discontinued TKI treatment, including IM, nilotinib, and dasatinib [5]. Nine out of the 27 patients surveyed developed musculoskeletal pain after discontinuing TKIs. In t

• What lies ahead Clearly the extremely ambitious goals

  2019-05-04

  

  What lies ahead? Clearly the extremely ambitious goals and targets set by the UNCoLSC have not been reached, and challenges must be overcome. While the current evaluation highlights several challenges and strategies for action, a clear process in moving forward would be to link this bottleneck analy

• Pharmacological inhibition of PI K

  2019-04-30

  

  Pharmacological inhibition of PI3Kα induces apoptosis of CLL 69 9 in vitro [5,18], and inhibits CLL migration towards CXCL12 [5]. The PI3Kα/δ inhibitor copanlisib induces significantly greater apoptosis of CLL cells compared to idelalisib (IC50 of 450nM and >10μM, respectively) in vitro and is curr

• br Acknowledgements br Introduction The chronic

  2019-04-30

  

  Acknowledgements Introduction The chronic myeloproliferative neoplasms (MPN) comprise a group of clonal stem cell disorders with a high prevalence of the JAK2 V617F mutation (JAK2+) causing excessive production of mature blood cells. Transformation to acute myeloid leukemia (AML) is seen in 2–

• br Introduction Atrial fibrillation AF is

  2019-04-30

  

  Introduction Atrial fibrillation (AF) is the most clinically prevalent tachyarrhythmia [1,2]. AF is a potential risk factor for stroke, and AF-associated strokes are often severe, resulting in disability or death [3–6]. Anticoagulant therapy with the vitamin K antagonist warfarin reduces the risk

• br Conflict of interest br Acknowledgments br

  2019-04-30

  

  Conflict of interest Acknowledgments Background of basic genetics The human genome contains approximately 3 billion nucleotide herpes simplex virus 1 pairs contained in 23 chromosome pairs. Each chromosome contains hundreds to thousands of genes and the estimated 30,000 genes in the human

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