• Su acci n en Chiapas fracas no s lo por

  2019-05-04

  

  Su acción en Chiapas fracasó, no sólo por el rechazo que generó entre los encomenderos sino también entre los religiosos que apoyaban la encomienda en beneficio propio o bien como mecanismo de cristianización acelerado. Cuando Las Casas regresa eg5 España, en lo que hace a su batalla de ideas, a la

• Regarding the expression of NKp NCR Fig

  2019-05-04

  

  Regarding the expression of NKp46/NCR1 (Fig. 1A and B), both increased and decreased expression are observed depending on patients. Interestingly, the expression of the inducible molecule NKp44/NCR2 is clearly induced in 3 patients (PT1, PT2 and PT5) both regarding the percentage and the MFI. In con

• In an earlier study we used a questionnaire

  2019-05-04

  

  In an earlier study, we used a questionnaire to assess musculoskeletal pain in patients with CML who had achieved DMR (MR4.0) and discontinued TKI treatment, including IM, nilotinib, and dasatinib [5]. Nine out of the 27 patients surveyed developed musculoskeletal pain after discontinuing TKIs. In t

• What lies ahead Clearly the extremely ambitious goals

  2019-05-04

  

  What lies ahead? Clearly the extremely ambitious goals and targets set by the UNCoLSC have not been reached, and challenges must be overcome. While the current evaluation highlights several challenges and strategies for action, a clear process in moving forward would be to link this bottleneck analy

• Pharmacological inhibition of PI K

  2019-04-30

  

  Pharmacological inhibition of PI3Kα induces apoptosis of CLL 69 9 in vitro [5,18], and inhibits CLL migration towards CXCL12 [5]. The PI3Kα/δ inhibitor copanlisib induces significantly greater apoptosis of CLL cells compared to idelalisib (IC50 of 450nM and >10μM, respectively) in vitro and is curr

• br Acknowledgements br Introduction The chronic

  2019-04-30

  

  Acknowledgements Introduction The chronic myeloproliferative neoplasms (MPN) comprise a group of clonal stem cell disorders with a high prevalence of the JAK2 V617F mutation (JAK2+) causing excessive production of mature blood cells. Transformation to acute myeloid leukemia (AML) is seen in 2–

• br Introduction Atrial fibrillation AF is

  2019-04-30

  

  Introduction Atrial fibrillation (AF) is the most clinically prevalent tachyarrhythmia [1,2]. AF is a potential risk factor for stroke, and AF-associated strokes are often severe, resulting in disability or death [3–6]. Anticoagulant therapy with the vitamin K antagonist warfarin reduces the risk

• br Conflict of interest br Acknowledgments br

  2019-04-30

  

  Conflict of interest Acknowledgments Background of basic genetics The human genome contains approximately 3 billion nucleotide herpes simplex virus 1 pairs contained in 23 chromosome pairs. Each chromosome contains hundreds to thousands of genes and the estimated 30,000 genes in the human

• La Constituci n espa ola de dispone

  2019-04-30

  

  La Constitución española de 1812 dispone bajo el nombre de América septentrional un territorio que desde California, Nuevo México y Texas hasta la Capitanía de Guatemala conforma una inmensa, compleja y rica estructura administrativa. Guatemala se separa poco antes de la jura de la Constitución de 1

• However transparency has declined rather than improved

  2019-04-30

  

  However, transparency has declined rather than improved. A recent analysis in the ranked PEPFAR as very poor—50th of 67 aid agencies worldwide. The report noted that, “PEPFAR does not disclose information on contracts to prime partners and sub-partners in a machine-readable and open format consisten

• THZ1 manufacturer Finally neither physiological factors such

  2019-04-29

  

  Finally, neither physiological factors, such as BMI, nor a history of hypertension, smoking, or alcohol consumption were associated with the status of anxiety. Music played during flexible sigmoidoscopy was reported to have decreased the mean arterial blood pressure and heart rate, but one study had

• Finally neither physiological factors such as BMI nor

  2019-04-29

  

  Finally, neither physiological factors, such as BMI, nor a history of hypertension, smoking, or alcohol consumption were associated with the status of anxiety. Music played during flexible sigmoidoscopy was reported to have decreased the mean arterial blood pressure and heart rate, but one study had

• In the present study we

  2019-04-29

  

  In the present study, we screened for the D85N polymorphism in 355 LQTS probands in which we could identify a mutation in KCNQ1, KCNH2, or SCN5A, and found 14 patients that carried the polymorphism in addition to a single pathologic LQTS-related gene mutation. Among them, in a family with KCNH2-E58K

• br Discussion Gangrene of extremities is generally

  2019-04-29

  

  Discussion Gangrene of extremities is generally attributed to arterial occlusion or poor perfusion due to shock, whereas venous gangrene is rare. The thrombophlebitic events in venous gangrene included three distinct phases: (1) phlegmasia alba dolens, (2) phlegmasia cerulea dolens (blue thrombop

• br Conflict of interest br Introduction

  2019-04-29

  

  Conflict of interest Introduction Gastric cancer is a major cause of cancer deaths worldwide, particularly in East Asia. Metastatic gastric cancer is associated with poor outcomes. The median overall survival of metastatic gastric cancer ranges from 9 to 13 months despite treated with systemic

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