• The repurposing of well characterized

  2022-01-06

  

  The repurposing of well-characterized and well-tolerated drugs in order to treat illnesses for which they were not originally intended has emerged as an attractive alternative to a long and costly process of drug development. Repositioning antihistaminergic ligands seems a promising idea given that

• En el caso de la

  2022-01-05

  

  En el caso de la foliculitis decalvante (FD), se ha publicado un estudio multicéntrico español de 82 pacientes en el que se concluye que el tratamiento que consigue una mayor efectividad (mejora en 15/15 pacientes tratados) y un mayor periodo de remisión postratamiento (7,2 meses) es la combinación

• br Conclusion br Author statement br Acknowledgments

  2022-01-05

  

  Conclusion Author statement Acknowledgments Introduction The hypothalamic-pituitary-gonadal (HPG) axis is an important neurohormone network for vertebrates that regulates their gonadal development and maturation, guarantees their pubertal development and maintains their normal reproducti

• br Presenilins in protein trafficking proteolysis and degrad

  2022-01-05

  

  Presenilins in protein trafficking, proteolysis and degradation An obvious explanation for the role of presenilins and γ-secretase in protein trafficking and degradation is that many reported γ-secretase substrates are functionally involved in protein transport. For example, members of the mammal

• The active site of PS is

  2022-01-05

  

  The active site of PS1 is located at the interior of its TM horseshoe-like fold (29) (Fig. 1). TM2 and TM6 serve as “doors” for substrate entry (30), as also observed in recent molecular dynamics (MD) simulations of the PS1 subunit (31). Recent coarse-grained (CG) and atomic simulations also showed

• Determination of enzyme activity differs

  2022-01-05

  

  Determination of enzyme activity differs from other analytical procedures. In this 1530 case, instead of enzyme concentration, a substrate depletion or product accumulation should be monitored. Such approach allows calculating activity basis of calibration curves performed for enzymatic reaction pr

• Due to the presence of

  2022-01-05

  

  Due to the presence of all FGFRs in the epithelium, there are several FGFs ligands that could be binding to these FGF receptors, namely FGFs 1–4, 8–10, 16 and 18–20. By evaluating the known roles of FGFs in epithelial-mesenchymal interactions and in bone development, this list can be reduced. For ex

• However Gingrich and Hen reported that absence

  2022-01-05

  

  However, Gingrich and Hen reported that absence of the gene at all stages of ontogenesis of mice may interfere with the normal developmental program and/or the organism may undergo changes in other systems to compensate for gene absence (46). In addition, potentially altered maternal behavior of GPR

• The Rho family of GTPases is composed of many small

  2022-01-05

  

  The Rho family of GTPases is composed of many small ubiquitous signaling G proteins that bind to guanosine triphosphate (GTP) and hydrolyze it to guanosine diphosphate (GDP). They act as switches: when binding to GTP, they are active and associate with a variety of target proteins that regulate intr

• Smoking is strongly and consistently associated

  2022-01-05

  

  Smoking is strongly and consistently associated with periodontitis in the general population. In our study we detected a similar pattern in patients with HIV infection: smokers had a higher DPSI score compared to non-smokers. The exact cause of smoking as a risk factor for periodontitis in the gener

• br Materials and methods br Results br

  2022-01-04

  

  Materials and methods Results Discussion Both EMT of the tubular epithelial LY500307 and the activation of fibroblasts are critical factors in the pathogenesis and progression of renal interstitial fibrosis. Accumulating evidence implicates EMT in the onset and pathogenesis of renal inters

• full text(pdf) We have previously established the pharmacoki

  2022-01-04

  

  We have previously established the pharmacokinetic profile and effective dose of MNF in the rat [43] and demonstrated the effectiveness of MNF as an anticancer drug in full text(pdf) and xenograft models [44]. Moreover, MNF was found to effectively block GPR55 signaling in tumor cells [21]. The com

• T L cells can be induced to differentiate into

  2022-01-04

  

  3T3-L1 cells can be induced to differentiate into adipocytes by the appropriate hormonal treatment and they offer a useful in vitro model system for adipogenesis. GPR120 mRNA was detected in differentiated mature adipocytes but not in confluent preadipocytes (Fig. 3A). The level of GPR120 mRNA incre

• In normal tissues the expression patterns of GPR and

  2022-01-04

  

  In normal tissues, the expression patterns of GPR120 and GPR40 are not uniform. GPR120 is highly expressed in adipocytes, lung and intestinal tract, while GPR40 is shown to be expressed in pancreatic islet find more info and intestinal tract [7], [20]. It is considered that the distribution of the

• We also observed a significantly higher SLC A gene

  2022-01-04

  

  We also observed a significantly higher SLC10A1 gene expression and NTCP protein level among metastatic individuals vs. donor livers. Na+/taurocholate co-transporting polypeptide (NTCP), which is expressed on the basolateral membrane of hepatocytes and is primarily responsible for the uptake of bile

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