• cytoskeleton However the Moon is not

  2021-03-04

  

  However, the Moon is not the only possible source for space resources. Asteroids, in particular near-Earth asteroids (NEAs), can provide an alternative source for propellant and other materials, sometimes at lower cost. There are an expected 4000 NEAs that require less propellant (delta-V) per trip

• MuRF interacts with four and a

  2021-03-04

  

  MuRF3 interacts with four-and-a-half LIM domain (FHL2) and γ-filamin leading to their degradation via UPS [64]. Conversely, abnormal aggregation of these proteins was observed in mice lacking MuRF3. Moreover, MuRF3-/- mice were found more prone to cardiac rupture after acute myocardial infarction (A

• p as a cyclin dependent kinase inhibitor exert significant n

  2021-03-04

  

  p21, as a cyclin-dependent kinase inhibitor, exert significant negative regulator of proliferation, and it could be transcriptional upregulated by p53 in order to impel transient Cholesterol arrest (Romanov et al., 2010). Using western blotting, we found that the protein expression of p21 upgrades

• The fact that the mean

  2021-03-04

  

  The fact that the mean tumor size of the E1202-654 + α-GalCer group was much smaller than that of the α-GalCer inoculated group in both protocols indicates that immunization with E1202-654 plus α-GalCer, which induces a strong CD8+ T cell E1 antigen-specific immune response, is involved in the elimi

• A set of small molecule

  2021-03-04

  

  A set of small molecule LigI inhibitors were identified through an in silico structure-based screen, using the atomic resolution structure of LigI complexed with nicked DNA [[18], [26]]. This screen yielded inhibitors that were selective for LigI (L82), inhibited both LigI and LigIII (L67) and inhib

• In addition we investigated if the previously reported papai

  2021-03-04

  

  In addition, we investigated if the previously reported papain inhibitor can inhibit rhodesain, and found that it was not active at inhibiting rhodesain. The vinyl sulfone analogue of () was then synthesized and tested, and it was also inactive towards rhodesain. We then determined the time dependen

• The isolation of a proteinaceous putative inhibitor of

  2021-03-04

  

  The isolation of a proteinaceous putative inhibitor of cysteine proteases from the extracts of Y. enterocolitica and E. coli was performed by affinity chromatography on immobilized and inactivated papain (Fig. 7A). Instead of the column variant of this technique (Tsushima et al., 1992), we used a ba

• Similarly to the chemokine CCL the

  2021-03-03

  

  Similarly to the chemokine CCL-5, the level of the chemokine SDF-1 in the groups of individuals with APD did not differ from its level in the control group. However, a slight increase in the level of this chemokine was recorded in the group of women and men with APD and PTSD as compared with the cor

• Currently multiple clinical trials of CSF CSF R

  2021-03-03

  

  Currently, multiple clinical trials of CSF-1/CSF-1R-targeting agents in combination with standard treatment modalities and immunotherapies are underway (Table 1). In particular, results for combinations with checkpoint blockade inhibitors and other immunotherapeutic approaches are eagerly awaited.

• Colony stimulating factor receptor CSF R or cFMS

  2021-03-03

  

  Colony stimulating factor-1 receptor (CSF-1R or cFMS) is a type III receptor tyrosine kinase. It is activated by binding with CSF-1 and IL-34, which stimulates differentiation, proliferation, survival and migration of monocyte-macrophage lineage cells., , , Also, macrophages produce inflammatory me

• No orthologs could be found in our B oleracea

  2021-03-03

  

  No orthologs could be found in our B. oleracea BAC library for AtCk1/2, which could mean that it is unique to Arabidopsis, or that we failed to detect it in our library. However, the second possibility is unlikely considering that Southern blotting analysis with four restriction enzymes disclosed fr

• We obtained two bands in RT

  2021-03-03

  

  We obtained two bands in RT-PCR for detection of SERPIN1-FOSB fusion when Taq DNA polymerase was used (Fig. 3A). Genuine RT-PCR product of SERPIN1-FOSB fusion was proved to be the shorter one (733 keap1 nrf2 pairs) by sequencing, and the longer band (863 base pairs) was shown to be derived from nat

• A factor that complicates the use of human

  2021-03-03

  

  A factor that complicates the use of human liver Wnt-C59 is one of variability, which arises in part because many of the human liver samples available for research show various stages of a variety of disease states (steatosis (fatty liver), cirrhosis, carcinogenesis in adjacent tissue), although ca

• br Methods br Results br Discussion Preclinical data indicat

  2021-03-03

  

  Methods Results Discussion Preclinical data indicate that nepicastat modulates sympathetic drive to the E3330 with a mild pressor effect in various animal models of hypertension (Stanney et al., 1998). However in this clinical study, the doses of nepicastat employed did not significantly a

• br Introduction Alzheimer s disease AD is the

  2021-03-03

  

  Introduction Alzheimer’s disease (AD) is the progressive version of mild cognitive impairment and usually met by the elderly population. It falls into the class of neurodegenerative disorders that attacks the DMPO nerves cells, or neurons, resulting in loss of memory, impairment of thinking and

16051 records 717/1071 page Previous Next First page 上5页 716717718719720 下5页 Last page