• S63845 and the Mitochondrial Apoptotic Pathway: A Transla...

  2025-09-28

  Explore how S63845, a potent MCL1 inhibitor, is redefining mitochondrial apoptotic pathway activation in hematological cancer research. This article uniquely integrates mechanistic insights with translational strategies, revealing new combinatorial and experimental frontiers.

• FLAG tag Peptide (DYKDDDDK): Enabling Quantitative Dissec...

  2025-09-27

  Discover how the FLAG tag Peptide (DYKDDDDK) empowers advanced recombinant protein purification and detection. This in-depth guide explores its role as an epitope tag for dissecting bidirectional transport and complex motor regulation, offering unique mechanistic insights that go beyond standard protocols.

• KU-60019: ATM Kinase Inhibition as a Precision Tool for G...

  2025-09-26

  Explore how KU-60019, a selective ATM kinase inhibitor, uniquely enables precision radiosensitization and metabolic reprogramming in glioma models. This in-depth analysis integrates advanced mechanistic insights and translational strategies for cancer research.

• Adenosine Triphosphate (ATP): Master Regulator of Mitocho...

  2025-09-25

  Explore how Adenosine Triphosphate (ATP) acts not only as a universal energy carrier but also as a central player in mitochondrial proteostasis and metabolic adaptation. This article provides a unique, in-depth analysis of ATP's emerging roles in regulating enzyme stability and signaling, advancing beyond existing perspectives.

• SM-164: Unraveling IAP Antagonism and Mitochondrial Apopt...

  2025-09-24

  Explore the mechanistic depth of SM-164, a bivalent Smac mimetic and IAP antagonist for cancer therapy. This article uniquely bridges IAP inhibition with emerging insights into mitochondrial apoptosis signaling, offering new perspectives for advanced cancer research.

• Panobinostat (LBH589): HDAC Inhibition, Epigenetics, and ...

  2025-09-23

  Explore the multifaceted applications of Panobinostat (LBH589), a potent hydroxamic acid-based histone deacetylase inhibitor, in epigenetic regulation research and apoptosis induction in cancer cells. This article highlights new mechanistic intersections linking HDAC inhibition, mitochondrial apoptosis, and emerging insights from RNA Pol II signaling.

• br Current therapies for metabolic diseases Inborn

  2025-03-03

  

  Current therapies for metabolic diseases Inborn errors of metabolism caused by deficiency of particular enzymes due to loss of function mutations or deletions have been treated by decreasing the intake of the enzymatic substrate, supplementation with an essential cofactor or vitamin, increasing m

• br Conclusion br Conflict of interest br

  2025-03-03

  

  Conclusion Conflict of interest Acknowledgements Introduction Human salivary aldehyde dehydrogenase (hsALDH) (E.C. 1.2.1.5) is the first line of defence against toxic aldehydes in the oral cavity. HsALDH is primarily a dimeric, class 3 ALDH (ALDH3A1) specific for aromatic and long/medium

• HT modulates cortical and hippocampal pyramidal cell functio

  2025-03-03

  

  5-HT modulates cortical and hippocampal pyramidal cell function in a very complex manner, since most 5-HT receptor subtypes (excitatory as well as inhibitory) are expressed on pyramidal AP 18 mg as well as GABAergic interneurons that exert inhibitory control over pyramidal cells (Leiser et al., 201

• We aim to evaluate the

  2025-03-03

  

  We aim to evaluate the AK in regulating adenosine signaling in the retina. It was reported that the degree of Quercitrin injury directly depends on expression levels of AK and the resulting extracellular levels of adenosine (Boison, 2006). Indeed, transgenic mice overexpressing AK are highly suscept

• The theoretical calculations of ADME

  2025-03-03

  

  The theoretical calculations of ADME parameters (molecular weight (MW), log P, topological polar surface are (tPSA), number of hydrogen donors (nON) and acceptors (nOHNH), and volume) and DLS are presented in along with the violations of Lipinski’s rule. According to these data, all compounds (–) c

• br Funding br Introduction The interest in the effects of

  2025-03-03

  

  Funding Introduction The interest in the effects of endocrine disrupting chemicals (EDCs) in the aquatic environment continues to increase over the past decade, specifically those that act on steroidogenic pathways. EDCs that include synthetic androgenic and estrogenic compounds can severely a

• br Dihydrotestosterone in adult fish and

  2025-03-03

  

  Dihydrotestosterone in adult fish and frogs New perspectives and next directions Similar to other androgens, DHT can modulate reproductive endpoints in both fish and amphibians. However, predicting the effects of DHT can be challenging, as reproductive homeostasis is dependent upon the balance

• A variety of quinazoline or fused

  2025-03-03

  

  A variety of quinazoline or fused pyrimidine-substituted diaminotriazoles showed sub-100nM inhibition of Axl (). Diaminotriazoles similarly substituted with quinolines, isoquinolines and benzothiazoles also showed potent Axl activity (data not shown), but generally exhibited potent cytotoxicity and

• The LOX hydroxide metabolites are converted to

  2025-03-01

  

  The 15-LOX hydroxide metabolites are converted to secondary lipid mediators such as lipoxin A4 from 15-HETE and protectin D1/resolvin D1 from 17-HDoHE [45] (Fig. S3). Importantly, all of these secondary lipid mediators have anti-inflammatory and pro-resolving properties [46], [47], [48]. Lipoxin A4

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