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GRP also known as immunoglobulin heavy chain
2020-08-07
GRP78, also known as immunoglobulin heavy chain BIP (binding protein), is an important molecular chaperone in recognizing and binding to unfolded proteins in ERS [23]. Under certain pathological conditions, unfolded proteins accumulate in the ER lumen and necessitate GRP78 dissociation, then induce
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We have reported previously that aminoacrylate derivatives o
2020-08-07
We have reported previously that β-aminoacrylate derivatives of the general structure () are inhibitors of DHODH. In particular, tricyclic derivatives and displayed sub-micromolar IC values against DHODH, and in the case of there was a 1000-fold greater potency compared to the human enzyme (DHODH).
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Compound was synthesized by the directed metallation procedu
2020-08-07
Compound () was synthesized by the directed -metallation procedure (DOM) at the stage of the amide using butyl lithium and dry ice as CO source for the introduction of the carboxylic group. Thiophene amides were prepared from commercial 3-thiophenecarboxylic Mesoridazine by conversion into the ac
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Funding sources This study was funded by European Community
2020-08-07
Funding sources This study was funded by European Community’s Seventh Framework Programme under grant agreement No. 305662 (Project: Community-based scheduled screening and treatment of malaria in pregnancy for improved maternal and infant health: a cluster-randomized trial ‘COSMIC’). Acknowledg
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GSK180 Dietary triglycerides are hydrolyzed in the small
2020-08-07
Dietary triglycerides are hydrolyzed in the small intestine by pancreatic lipase to monoacylglycerol and fatty acids, which are then absorbed by the enterocytes and recombined into triglycerides by a series of sequential esterification steps, the final of which is catalyzed by acyl CoA:diacylglycero
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Taking a pragmatic approach with a view to
2020-08-06
Taking a pragmatic approach with a view to complete the study and because chemotherapy regimens in NETs are not standardized, we do not impose a specific regimen in both arms. However, one regimen in each arm is recommended in order to reduce heterogeneity: the ALKY-based chemotherapy arm will recei
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We previously reported that the changes in
2020-08-06
We previously reported that the changes in the expression level of DGKδ2 affect C2C12 myogenic differentiation [39]. Proteostasis requires both protein synthesis and degradation. Indeed, protein degradation via the ubiquitin-proteasome and autophagy-lysosome systems is important for skeletal muscle
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br Competing interests br Acknowledgements This work was
2020-08-06
Competing interests Acknowledgements This work was supported by a Grant-in-Aid for Scientific Research (KAKENHI) from the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) (26304036), Japan. Introduction Cancer is a disease of dysregulated cell growth and metabolism-re
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In vitro work by us
2020-08-06
In vitro work by us and others revealed that high affinity interaction with collagen requires dimerization and/or pre-oligomerization of DDR1 (Agarwal et al., 2007, Abdulhussein et al., 2008, Leitinger, 2003). It has also been reported that a significant percentage of the DDR1 population forms ligan
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The pressure function is is a structural parameter
2020-08-06
The pressure function is: is a structural parameter equal to 0.4242 K/bar for structure I and 1.0224 K/bar for structure II, where the activity function is: And,Where , and are adjustable parameters which can be obtained by optimizing the experimental data for a particular hydrate structure and a
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Amidoxime and oxadiazole containing compounds showed
2020-08-06
Amidoxime and 1,2,4-oxadiazole containing compounds showed significant pharmacological effects as antihyperglycemic activity, anti-inflammatory activity, antimycobacterial activity, muscarinic agonist activity and serotonergic inhibitory activity, peptide inhibitory activity [27], [28], [29], [30].
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Previous studies reported that NE and
2020-08-05
Previous studies reported that NE and MHPG are deeply involved in depression and that NE reuptake inhibitors are approved for use in patients with depression (for review, see [2]). We found increased hippocampal content of NE and MHPG in the CORT-treated CRTH2−/− mice (Fig. 3). In the hippocampus, a
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XEN445 mg Nitric oxide NO was reported to inhibit HPHs altho
2020-08-05
Nitric oxide (NO) was reported to inhibit HPHs, although its inhibitory mechanism remains controversial [9], [10]. For catalytic hydroxylation of HIF-1α, dioxygen (O2) binds to Fe(II) in the active site of HPHs [11]. NO is a molecular mimic for O2 binding as an Fe(II) ligand. Indeed, high resolution
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We also used an affinity purification approach
2020-08-05
We also used an affinity purification approach and subsequent mass spectrometry analysis to explore the interacting proteins with METTL8, and found a number of RNA binding proteins in the candidates list (Table S3). This result suggests that the binding between METTL8 and Mapkbp1 mRNA may be not dir
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The vascular endothelium is a highly
2020-08-04
The vascular endothelium is a highly dynamic multifunctional organ that is critically involved in the regulation of vessel integrity, vascular growth and remodeling, tissue growth and metabolism, immune responses, cell adhesion, angiogenesis, hemostasis and vascular permeability [23]. Therefore, the
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