• The final test that was performed was

  2020-01-15

  

  The final test that was performed was to determine whether the trigger points of the current limiters are stable across a wide temperature range. This test was performed within a thermal-vacuum chamber on each current limiter individually. All the current limiter trip currents were set to approximat

• br The modulation of ER

  2020-01-15

  

  The modulation of ERα: from SERMs to TSECs Continued efforts to provide women with efficacious menopausal therapies have generated interest in the development of selective VX-702 receptor modulators (SERMs). Similar to estrogens, SERMs have been shown to bind to ERs with high affinity, despite l

• It is very important to decide

  2020-01-15

  

  It is very important to decide what the best time of NIR laser irradiation is for the optimized PTT. So the best way is to monitor the biodistribution of the nanoparticles in various tissues (specially, in tumors) temporally and spatially after iv injection. Based on the combined functions of therap

• Early VL diagnosis makes it

  2020-01-14

  

  Early VL diagnosis makes it possible to formulate a quicker and more effective treatment against the disease, which could increase the possibility of a cure for the patients, as well as reduce the toxicity of the drugs (Coelho et al., 2009); however, conventional and molecular parasitological method

• br DDR receptor and MMP expression Type II

  2020-01-14

  

  DDR2 receptor and MMP-13 expression Type II collagen protein in articular cartilage is highly stable structure as its half-life is 117 years [43]. The chondrocytes have limited ability to synthesis type II collagen protein in the matrix of mature articular cartilage once the collagen gets disrupt

• br Conclusion The present study is the first to

  2020-01-14

  

  Conclusion The present study is the first to provide in vivo evidence that the σ1R deficiency can cause age-related increases in aggregation and phosphorylation of αSyn in dopaminergic neurons of SNpc. The σ1R has been reported to be decreased in the ras pathway region of the nigrostriatal dopam

• br Conclusion AS SP the first line

  2020-01-14

  

  Conclusion AS+SP, the first-line treatment, still remains highly effective in Pakistan following its introduction in 2007. However, molecular data indicate that SP resistance is being established in Pakistan, although mutations that confer a high risk of SP treatment failure are rare or non-exist

• Having generated synthetic cytokines and synthetic cytokine

  2020-01-14

  

  Having generated synthetic cytokines and synthetic cytokine receptors, the logical next step has been to design fully synthetic cytokine/cytokine receptor systems, modifying either cytokine/cytokine receptor binding interfaces or cytokine-unrelated combinations of substances and their binding domain

• RNA sequencing RNA seq is a

  2020-01-14

  

  RNA-sequencing (RNA-seq) is a particularly effective technology for gene discovery in a given process, especially in non-model species for which reference genome sequences are not available. Although the major application of RNA-seq analyses is the identification of differentially expressed genes (D

• Three dimensional conformational changes in the

  2020-01-14

  

  Three-dimensional conformational changes in the cargo protein’s NES, caused by protein phosphorylation, dephosphorylation, or mutation, can regulate CRM1 binding (Craig et al., 2002, Vogt et al., 2005). Additional protein modifications such as sumoylation, ubiquitination, acetylation, and/or the bin

• These findings further extend our knowledge of how P and

  2020-01-14

  

  These findings further extend our knowledge of how P4 and/or E2 can mediate anxiety and fear responses. Female rats in behavioral estrous and ovx rats administered systemic P4 and/or E2 demonstrated significantly less anxiety in the open field and/or elevated plus maze, compared to diestrous rats, a

• kobe2602 p and p which are downstream of pAkt and

  2020-01-14

  

  p21 and p16, which are downstream of pAkt and pERK1/2, are tumor suppressors which induce cell senescence and kobe2602 arrest [[56], [57], [58]]. Inhibitors of pAkt or pERK1/2 can activate p21 and p16 and promote cell senescence and cell cycle arrest [11,12,[59], [60], [61]]. It is well known that

• A major open question in the field of lipid mediators

  2020-01-14

  

  A major open question in the field of lipid mediators is the molecular nature of the PLA2 enzyme involved in the release of DHA and related omega-3 fatty acids from phospholipids as a first committed step for the generation of SPMs. Although by analogy with AA it is often assumed that cPLA2α may ser

• A growing body of data indicates that endothelial

  2020-01-14

  

  A growing body of data indicates that endothelial NOS (eNOS) is a rate-limiting enzyme for the synthesis of nitric oxide (NO), its downstream GDC-0879 molecule. High pathological concentrations of NO produced from inducible NO synthase (iNOS) induce apoptosis, whereas a reduction in the concentrati

• The genes corresponding to TVAG TVAG TVAG

  2020-01-14

  

  The genes corresponding to TVAG_263740, TVAG_487600, TVAG_282090, TVAG_170370, and TVAG_148010 seem to be the less expressed, and undetectable by proteomics approach. In comparison, in other T. vaginalis strains, and experimental conditions, they show very few or null EST\'s reports [4]. Concludi

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